Qi Wen Fan, MD, PhD

Associate Adjunct Professor
Neurology
[email protected]
+1 415 502-1695 ext. 2
Publications: 

Brain-restricted mTOR inhibition with binary pharmacology.

Nature

Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM

Betacellulin drives therapy resistance in glioblastoma.

Neuro-oncology

Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.

Cancer research

Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW

DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA.

Neuro-oncology

Qi Wen Fan, Edward Lorenzana, Xujun Luo, Robin Lea, Ozlem Aksoy, Zhenyi An, Tomoko Ozawa, Douglas Wassarman, Kevan Shokat, James Aggen, Jaqueline A M Smith, Mallika Singh, Nicholas Butowski, David Raleigh, William Weiss

THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA.

Neuro-oncology

Xujun Luo, Qi-Wen Fan, Kevan M Shokat, William A Weiss

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.

Cancer research

An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA

CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA.

Neuro-oncology

Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss

Inhibiting 4EBP1 in Glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Fan QW, Nicolaides TP, Weiss WA

Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma.

Understanding and Targeting Oncogenic Translation Control in Different Human Cancers

QiWen Fan, Ozlem Aksoy, Robyn Wong, Shirin Ilkhanizadeh, Chris Novotny, William Gustafson, Albert Tuong, Geraldine Cayanan, Erin Simonds, Daphne Haas-Kogan, Joanna Phillips, Theo Nicolaides, Theo Nicolaides, Masanori Okaniwa, Kevan Shokat, William A. Weiss

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Cancer cell

Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA

Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas.

Journal of neuro-oncology

Zhang J, Yao TW, Hashizume R, Hariono S, Barkovich KJ, Fan QW, Prados M, James CD, Weiss WA, Nicolaides T

ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA.

Neuro-oncology

QiWen Fan, Robyn Wong, Chris Novotny, Masanori Okaniwa, Theodore Nicolaides, Kevan Shokat, William Weiss

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.

Cell reports

Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA

MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA.

Neuro-oncology

William A. Weiss, Robyn Wong, Qi-Wen Fan, Shirin Ilkhanizadeh, Mimi Lu, Janine Beyer, Nikhil Dube, John Forsayeth, Adrian Kells, Ting Xu, Krystof Bankiewicz, Greg Ducker, Morri Feldman, Kevan Shokat

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.

Cancer cell

Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA

Abstract 5683: Blockade of glioma proliferation via allosteric inhibition of JAK2.

Cancer Chemistry

Kunyan He, Qi Qi, Chi-Bun Chan, Ge Xiao, Xia Liu, Carol Tucker-Burden, Liya Wang, Hui Mao, Xiang Lu, Frank E. McDonald, Hongbo Luo, Qi-wen Fan, William A. Weiss, Shi-yong Sun, Daniel J. Brat, Keqiang Ye

Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

Methods in molecular biology (Clifton, N.J.)

Fan QW, Weiss WA

Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy.

Cancer Chemistry

Krister J. Barkovich, Theodore Nicolaides, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss

Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Science signaling

Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA

Pleiotropic role for MYCN in medulloblastoma.

Genes & development

Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L

Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy.

Experimental and Molecular Therapeutics

Theodore P. Nicolaides, Krister Barkovich, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss

Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.

Current topics in microbiology and immunology

Fan QW, Weiss WA

EGFR signals to mTOR through PKC and independently of Akt in glioma.

Science signaling

Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA

PI3K signaling in glioma--animal models and therapeutic challenges.

Brain pathology (Zurich, Switzerland)

Cheng CK, Fan QW, Weiss WA

Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.

EMBO reports

Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.

Cancer research

Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA

39 Glioma.

Neurobiology of Disease

Anders I. Persson, QiWen Fan, Joanna J. Phillips, William A. Weiss

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.

Cancer cell

Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA

Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.

Cancer research

Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA

Tri-service physician's assistants programs.

Military medicine

Robinson HA, Thompson HW