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The laboratory of William A. Weiss at the University of California, San Francisco is broadly interested in developing and characterizing mouse models that faithfully recapitulate the biology and genetics of human tumors of the nervous system, and using observations in the mouse to inform the biology, genetics, and therapy of human tumors. Specifically, we are:

1) Identifying the subsequent genetic events that promote tumorigenesis.
2) Studying cancer stem and progenitor cells to understand their contribution to malignant progression.
3) Evaluating new targets, therapies, and mechanistic rationales for combining targeted agents.