Hiroyuki Yoda, PhD

Specialist
[email protected]
+1 415 502-1694
Publications: 

ALK upregulates POSTN and WNT signaling to drive neuroblastoma.

Cell reports

Huang M, Fang W, Farrel A, Li L, Chronopoulos A, Nasholm N, Cheng B, Zheng T, Yoda H, Barata MJ, Porras T, Miller ML, Zhen Q, Ghiglieri L, McHenry L, Wang L, Asgharzadeh S, Park J, Gustafson WC, Matthay KK, Maris JM, Weiss WA

Use of DNA-alkylating pyrrole-imidazole polyamides for anti-cancer drug sensitivity screening in pancreatic ductal adenocarcinoma.

Cancer medicine

Tsujimoto A, Matsuo N, Lai X, Inoue T, Yoda H, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H

CD133 prevents colon cancer cell death induced by serum deprivation through activation of Akt-mediated protein synthesis and inhibition of apoptosis.

FEBS open bio

Mori Y, Takeuchi A, Miyagawa K, Yoda H, Soda H, Nabeya Y, Watanabe N, Ozaki T, Shimozato O

An expanded universe of cancer targets.

Cell

Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS, Cancer Target Discovery and Development Network

Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer.

Cancer science

Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H

Vitamin K3 derivative induces apoptotic cell death in neuroblastoma via downregulation of MYCN expression.

Biochemistry and biophysics reports

Yoda H, Nakayama T, Miura M, Toriyama M, Motohashi S, Suzuki T

PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133.

FEBS open bio

Matsushita M, Mori Y, Uchiumi K, Ogata T, Nakamura M, Yoda H, Soda H, Takiguchi N, Nabeya Y, Shimozato O, Ozaki T

Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach.

PloS one

Lin J, Krishnamurthy S, Yoda H, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Horton P, Nagase H

Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma.

Cancer research

Yoda H, Inoue T, Shinozaki Y, Lin J, Watanabe T, Koshikawa N, Takatori A, Nagase H

Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death.

Oncogenesis

Nakamura M, Sugimoto H, Ogata T, Hiraoka K, Yoda H, Sang M, Sang M, Zhu Y, Yu M, Shimozato O, Ozaki T

Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.

Cell death discovery

Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O, Nagase H, Ozaki T

Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.

Nature communications

Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H

Vitamin K3 analogs induce selective tumor cytotoxicity in neuroblastoma.

Biological & pharmaceutical bulletin

Kitano T, Yoda H, Tabata K, Miura M, Toriyama M, Motohashi S, Suzuki T