Qi Wen Fan, MD, PhD

EGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma.

Neuro-oncology

An Z, Fan QW, Wang L, Yoda H, Barata MJ, Jimenez-Morales D, Phillips JJ, Swaney DL, Stevenson E, Lee E, Krogan N, Weiss WA

Brain-restricted mTOR inhibition with binary pharmacology.

Nature

Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM

Betacellulin drives therapy resistance in glioblastoma.

Neuro-oncology

Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.

Cancer research

Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW

DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA.

Neuro-oncology

Qi Wen Fan, Edward Lorenzana, Xujun Luo, Robin Lea, Ozlem Aksoy, Zhenyi An, Tomoko Ozawa, Douglas Wassarman, Kevan Shokat, James Aggen, Jaqueline A M Smith, Mallika Singh, Nicholas Butowski, David Raleigh, William Weiss

THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA.

Neuro-oncology

Xujun Luo, Qi-Wen Fan, Kevan M Shokat, William A Weiss

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.

Cancer research

An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.

Oncogene

An Z, Aksoy O, Zheng T, Fan QW, Weiss WA

CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA.

Neuro-oncology

Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss

Inhibiting 4EBP1 in Glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Fan QW, Nicolaides TP, Weiss WA

Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma.

Understanding and Targeting Oncogenic Translation Control in Different Human Cancers

QiWen Fan, Ozlem Aksoy, Robyn Wong, Shirin Ilkhanizadeh, Chris Novotny, William Gustafson, Albert Tuong, Geraldine Cayanan, Erin Simonds, Daphne Haas-Kogan, Joanna Phillips, Theo Nicolaides, Theo Nicolaides, Masanori Okaniwa, Kevan Shokat, William A. Weiss

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Cancer cell

Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA

Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas.

Journal of neuro-oncology

Zhang J, Yao TW, Hashizume R, Hariono S, Barkovich KJ, Fan QW, Prados M, James CD, Weiss WA, Nicolaides T

ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA.

Neuro-oncology

QiWen Fan, Robyn Wong, Chris Novotny, Masanori Okaniwa, Theodore Nicolaides, Kevan Shokat, William Weiss

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.

Cell reports

Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA

MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA.

Neuro-oncology

William A. Weiss, Robyn Wong, Qi-Wen Fan, Shirin Ilkhanizadeh, Mimi Lu, Janine Beyer, Nikhil Dube, John Forsayeth, Adrian Kells, Ting Xu, Krystof Bankiewicz, Greg Ducker, Morri Feldman, Kevan Shokat

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.

Cancer cell

Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA

Abstract 5683: Blockade of glioma proliferation via allosteric inhibition of JAK2.

Cancer Chemistry

Kunyan He, Qi Qi, Chi-Bun Chan, Ge Xiao, Xia Liu, Carol Tucker-Burden, Liya Wang, Hui Mao, Xiang Lu, Frank E. McDonald, Hongbo Luo, Qi-wen Fan, William A. Weiss, Shi-yong Sun, Daniel J. Brat, Keqiang Ye

Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

Methods in molecular biology (Clifton, N.J.)

Fan QW, Weiss WA

Autophagy and Akt promote survival in glioma.

Autophagy

Fan QW, Weiss WA

Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy.

Cancer Chemistry

Krister J. Barkovich, Theodore Nicolaides, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss

Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Science signaling

Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA

Pleiotropic role for MYCN in medulloblastoma.

Genes & development

Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L

Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy.

Experimental and Molecular Therapeutics

Theodore P. Nicolaides, Krister Barkovich, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.

Cancer research

Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA

Publications

EGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma.

Brain-restricted mTOR inhibition with binary pharmacology.

Betacellulin drives therapy resistance in glioblastoma.

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.

DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA.

THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA.

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.

CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA.

Inhibiting 4EBP1 in Glioblastoma.

Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma.

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas.

ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA.

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.

MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA.

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.

Abstract 5683: Blockade of glioma proliferation via allosteric inhibition of JAK2.

Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

Autophagy and Akt promote survival in glioma.

Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy.

Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Pleiotropic role for MYCN in medulloblastoma.

Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy.

Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.

EGFR signals to mTOR through PKC and independently of Akt in glioma.

PI3K signaling in glioma--animal models and therapeutic challenges.

Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.

39 Glioma.

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.

RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.

Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.

Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.

Tri-service physician's assistants programs.